Starting out soon- Combat, Support and Crafting class synergies?

[Don Bonnigan]

Hi, as I said, I just downloaded this mod, and am going to start later today. I just have some questions about what classes to choose.

I want to go with the skirmisher line. In general, do skirmishers make better medics or engineers? I assume the higher speed lets them medic better, but I'm not sure. If I do go with medic, should I then choose the alchemist as my crafting class, or would black or armor smith better for DPS /defense?

I just want to know if synergy really matters much, or if I should just choose what I like.

Thanks.